Abstract |
This manuscript reports on a patient with a metastatic gastrointestinal stromal tumor (GIST) refractory to standard first-line treatment, who underwent a gallium-68 scan based on pre-clinical data of somatostatin receptor (SSTR) expression in such tumors. The gallium-68 DOTATATE scan determined significant somatostatin receptor avidity as hypothesized, suggesting that this imaging modality may be used as an option for diagnostic and follow-up purposes in GIST patients. In addition, peptide receptor-mediated radiotherapy (177Lu-PPRT) via SSTR may provide a novel treatment strategy in carefully selected SSTR-avid GIST patients with thyrosine kinase inhibitor (TKI)-resistant tumors such as this case, and this warrants further investigation in novel clinical trial concepts.
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Authors | Arturo Loaiza-Bonilla, Paula A Bonilla-Reyes |
Journal | Cureus
(Cureus)
Vol. 9
Issue 9
Pg. e1710
(Sep 24 2017)
ISSN: 2168-8184 [Print] United States |
PMID | 29188154
(Publication Type: Case Reports)
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