Immunogenicity and Protection From a Single Dose of Internationally Available Killed Oral Cholera Vaccine: A Systematic Review and Metaanalysis.

Abstract

In addition to improved water supply and sanitation, the 2-dose killed oral cholera vaccine (OCV) is an important tool for the prevention and control of cholera. We aimed to document the immunogenicity and protection (efficacy and effectiveness) conferred by a single OCV dose against cholera. The metaanalysis showed that an estimated 73% and 77% of individuals seroconverted to the Ogawa and Inaba serotypes, respectively, after an OCV first dose. The estimates of single-dose vaccine protection from available studies are 87% at 2 months decreasing to 33% at 2 years. Current immunologic and clinical data suggest that protection conferred by a single dose of killed OCV may be sufficient to reduce short-term risk in outbreaks or other high-risk settings, which may be especially useful when vaccine supply is limited. However, until more data suggest otherwise, a second dose should be given as soon as circumstances allow to ensure robust protection.

• Authors: Anna Lena Lopez, Jacqueline Deen, Andrew S Azman, Francisco J Luquero, Suman Kanungo, Shanta Dutta, Lorenz von Seidlein, David A Sack
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 66 Issue 12 Pg. 1960-1971 (06 01 2018) ISSN: 1537-6591 [Electronic] United States
• PMID: 29177437 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Systematic Review)

Chemical References

• Cholera Vaccines
• Vaccines, Inactivated

Topics

• Administration, Oral
• Cholera (prevention & control)
• Cholera Vaccines (administration & dosage, immunology)
• Disease Outbreaks (prevention & control)
• Humans
• Immunization Schedule
• Immunogenicity, Vaccine
• Seroconversion
• Serogroup
• Vaccination (methods)
• Vaccine Potency
• Vaccines, Inactivated (administration & dosage, immunology)
• Vibrio cholerae (immunology)