Gallbladder motility before and after extracorporeal shock-wave lithotripsy.

Abstract

To determine whether extracorporeal shock-wave lithotripsy of gallbladder stones alters gallbladder motility, gallbladder contraction in response to intravenous cholecystokinin was investigated by ultrasound. Twenty-one patients with symptomatic gallstones were studied before and after shock-wave lithotripsy, 12 with and 9 without concomitant litholytic therapy (combination of ursodeoxycholic acid and chenodeoxycholic acid). Gallbladder emptying was significantly delayed and less complete in both groups of patients before shock-wave treatment (with bile salts: residual volume, 51% +/- 10% and half-ejection time, 40 +/- 5 min; without bile salts: residual volume, 46% +/- 7%; half-ejection time, 30 +/- 4 min) compared with healthy controls (residual volume, 15% +/- 4%; half-ejection time, 18 +/- 2 min). Gallbladder motility was not altered in either group 1 day and 1 yr after lithotripsy. The findings indicate (a) that extracorporeal shock-wave lithotripsy has no immediate or long-term adverse effects on gallbladder motility and (b) that the defect of gallbladder motility associated with gallstone disease is not abolished by removal of the stone.

• Authors: U Spengler, M Sackmann, T Sauerbruch, J Holl, G Paumgartner
• Journal: Gastroenterology (Gastroenterology) Vol. 96 Issue 3 Pg. 860-3 (Mar 1989) ISSN: 0016-5085 [Print] United States
• PMID: 2914646 (Publication Type: Journal Article)

Chemical References

• Chenodeoxycholic Acid
• Ursodeoxycholic Acid
• Cholecystokinin

Topics

• Adult
• Chenodeoxycholic Acid (therapeutic use)
• Cholecystokinin
• Cholelithiasis (physiopathology, therapy)
• Female
• Gallbladder (physiopathology)
• Humans
• Lithotripsy
• Male
• Middle Aged
• Muscle Contraction
• Peristalsis
• Ursodeoxycholic Acid (therapeutic use)