[The difference expression and diagnostic value of RPL5 in papillary thyroid carcinoma of children and adults].

Abstract

Objective: To study the difference expression and diagnostic value of ribosomal protein L5 (RPL5) in papillary thyroid carcinoma (PTC) of children and adults. Methods: Realtime-PCR was performed to detect the expression of RPL5 in 22 PTC tissues and 13 pericarcinous tissues. Receiver operating characteristic (ROC) curve and Youden's index were used to evaluate the diagnostic value of RPL5 in PTC of children and adults. Results: The expression of RPL5 in PTC tissues was higher than in pericarcinous tissues. The area under curve (AUC) was 0.820 (P=0.001), and Youden's index was 0.568. The expression of RPL5 in PTC of adults was higher than children (P<0.05). The AUC and Youden's index were respectively 0.721 (P=0.069) and 0.414 in children, whereas being respectively 0.896 (P=0.0005) and 0.709 in adults. RPL5 in diagnosis of PTC of adults was better than CK19, Galectin-3 and TPO, which are commonly used for the pathologic diagnosis of PTC. Conclusion: The expression of RPL5 in PTC is higher than pericarcinous tissues, and its expression in PTC of adults is higher than children. Furthermore, PTC is a potential indicator for diagnosis of PTC.

• Authors: Y Q Jin, S C Wang, J Tai, J Zhang, F Chen, J Shi, Y B Yu, Y R Yang, H M Ren, D Geng, Y H Liu, Y L Guo, X Ni
• Journal: Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery (Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi) Vol. 52 Issue 11 Pg. 830-834 (Nov 07 2017) ISSN: 1673-0860 [Print] China
• PMID: 29141292 (Publication Type: Journal Article)

Chemical References

• Autoantigens
• Biomarkers, Tumor
• Galectin 3
• Iron-Binding Proteins
• Ribosomal Proteins
• ribosomal protein L5, human
• TPO protein, human
• Iodide Peroxidase

Topics

• Adult
• Autoantigens (metabolism)
• Biomarkers, Tumor (metabolism)
• Carcinoma, Papillary (diagnosis, metabolism)
• Child
• Galectin 3 (metabolism)
• Humans
• Iodide Peroxidase (metabolism)
• Iron-Binding Proteins (metabolism)
• ROC Curve
• Real-Time Polymerase Chain Reaction
• Ribosomal Proteins (metabolism)
• Thyroid Cancer, Papillary
• Thyroid Neoplasms (diagnosis, metabolism)