Abstract | BACKGROUND: METHODS: A cross-sectional questionnaire-based study on 85 patients with mitochondrial disease with different genotypes and phenotypes was conducted between 2010 and 2011. A structured headache questionnaire according to ICHD-2 was used followed by a telephone interview by a headache expert. Prevalence and characteristics of headache could be analyzed in 42 patients. Headache diagnosis was correlated with genotypes and phenotypes. In addition, the mtDNA haplotype H was analyzed. RESULTS:
Headache was reported in 29/42 (70%; 95% CI, from 55.1 to 83.0%) of the patients. Tension-type headache (TTH) showed the highest prevalence in 16/42 (38%; 95% CI, from 23.4 to 52.8%) patients, followed by migraine and probable migraine in 12/42 (29%; 95% CI, from 14.9 to 42.2%) patients. Nine of the 42 (21%; 95% CI, from 9 to 33.8%) patients reported two different headache types. Patients with the mtDNA mutation m.3243A > G (n = 8) and MELAS (n = 7) showed the highest prevalence of headaches (88% and 85%, respectively). In patients with the CPEO phenotype (n = 32), headache occurred in 14/18 (78%; 95% CI, from 58.6 to 97%) of patients with single deletions, and in 7/13 (54%; 95% CI, from 26.7 to 80.9%) patients with multiple mtDNA deletions. There were no association between the mtDNA haplotype Hand the headache-diagnosis. CONCLUSIONS:
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Authors | Torsten Kraya, Marcus Deschauer, Pushpa Raj Joshi, Stephan Zierz, Charly Gaul |
Journal | Headache
(Headache)
Vol. 58
Issue 1
Pg. 45-52
(Jan 2018)
ISSN: 1526-4610 [Electronic] United States |
PMID | 29139113
(Publication Type: Journal Article)
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Copyright | © 2017 American Headache Society. |
Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Cross-Sectional Studies
- DNA, Mitochondrial
(genetics)
- Female
- Genotype
- Headache
(epidemiology, etiology)
- Humans
- Male
- Middle Aged
- Mitochondrial Diseases
(complications, epidemiology, genetics)
- Mutation
(genetics)
- Phenotype
- Prevalence
- Surveys and Questionnaires
- Young Adult
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