The effect and safety of anacetrapib in the treatment of dyslipidemia: a systematic review and meta-analysis.

Abstract

BACKGROUND:

Cardiovascular disease (CVD) is the major cause of morbidity and mortality worldwide. Anacetrapib may be a new treatment option that has a cardiovascular benefit for the management of dyslipidemia.

OBJECTIVE:

The aim of our current study was to perform a systematic review and meta-analysis of all randomized controlled trials (RCTs) assessing the effect and safety of anacetrapib in the treatment of dyslipidemia.

METHODS:

We systematically searched PubMed, Embase, and Cochrane Library database from their inception to 5 October 2017, with the terms: 'anacetrapib' and 'placebo'. From 287 initial citations, 10 studies including 34781 patients with dyslipidemia were included in the final systematic review and meta-analysis.

RESULTS:

Pooled results showed that anacetrapib significantly increased high density lipoprotein cholesterol (HDL-C) [weighted mean differences (WMD) 53.07, 95% confidence interval (95% CI) 46.79 to 59.36] and apolipoprotein AI (ApoAI) (WMD 53.44, 95% CI 45.72 to 61.16). Our study also showed that anacetrapib significantly reduced low density lipoprotein cholesterol (LDL-C) (WMD -32.99; 95% CI -37.13 to -28.86), Non-HDL-C (WMD -39.19; 95% CI -52.22 to -26.16), triglycerides (TG) (WMD -9.97; 95% CI -10.54 to -9.41), apolipoprotein B (ApoB) (WMD -22.55; 95% CI -28.56 to -16.54) and lipoprotein a [LP(a)] (WMD -13.35; 95% CI -18.31 to -8.39). Our results demonstrated that there was no significant difference in all the following adverse events between the anacetrapib group and placebo group: [hepato-toxicity (OR 0.90, 95% CI: 0.75 to 1.07); musculoskeletal injury (OR 1.01, 95% CI: 0.88 to 1.15); drug-related adverse event (OR 1.00, 95% CI: 0.96 to 1.05); drug-related withdrawn (OR 1.01, 95% CI: 0.95 to 1.08)].

CONCLUSIONS:

Although further studies are needed, our findings clearly offer support to the use of anacetrapib in the clinical management of patients with dyslipidemia.

• Authors: Junteng Zhou, Qi Zhang, Yushu Wang, Peijuan Gao, Decai Chen
• Journal: Postgraduate medicine (Postgrad Med) Vol. 130 Issue 1 Pg. 129-136 (Jan 2018) ISSN: 1941-9260 [Electronic] England
• PMID: 29135318 (Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)

Chemical References

• Anticholesteremic Agents
• Oxazolidinones
• anacetrapib

Topics

• Anticholesteremic Agents (therapeutic use)
• Dyslipidemias (drug therapy)
• Humans
• Oxazolidinones (therapeutic use)