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Infused L-histidinol and cisplatin: schedule, specificity, and proliferation dependence.

Abstract
The dose and schedule requirements found for the combination of L-histidinol and 5-fluorouracil (5-FU) were concordant with those for the combination of L-histidinol and cisplatin. Furthermore, cisplatin-L-histidinol was active against colon 26 tumor, an adenocarcinoma that developed in a BALB/c female mouse and that has been grown as a solid tumor. The toxicity of cisplatin was prevented only when cisplatin was given before L-histidinol. Studies of L-histidinol and 5-FU had similar results. For (DBA/2 X BALB/c)F1 mice, 50 mg of L-histidinol per mouse was required for protection; for hematopoietic precursor cells, protection was dependent on the dose of L-histidinol. In contrast, both L1210 leukemia cells and colon 26 adenocarcinoma cells were more efficiently killed by combinations of L-histidinol and cisplatin. This effect depended on the doses of L-histidinol and cisplatin, a finding similar to the finding for hematopoietic precursor cells.
AuthorsM B Edelstein
JournalJournal of the National Cancer Institute (J Natl Cancer Inst) Vol. 81 Issue 4 Pg. 298-301 (Feb 15 1989) ISSN: 0027-8874 [Print] United States
PMID2913328 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Histidinol
  • Cisplatin
Topics
  • Adenocarcinoma (drug therapy, pathology)
  • Animals
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use, toxicity)
  • Cell Division (drug effects)
  • Cell Survival (drug effects)
  • Cisplatin (administration & dosage)
  • Colonic Neoplasms (drug therapy, pathology)
  • Colony-Forming Units Assay
  • Dose-Response Relationship, Drug
  • Hematopoietic Stem Cells (drug effects)
  • Histidinol (administration & dosage)
  • Leukemia L1210 (drug therapy)
  • Mice
  • Mice, Inbred Strains

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