[Drug combination characteristics of Shenxiong glucose injection in treating ischemic cerebrovascular disease in real world].

Abstract

To analyze the clinical drug use characteristics of Shenxiong glucose injection in the treatment of ischemic cerebrovascular disease. From hospital information system (HIS) of 19 hospitals over China, the basic information of patients with Shenxiong glucose injection for ischemic cerebrovascular disease, traditional Chinese medicine and Western medicine diagnosis information, order information, and laboratory examination information were extracted. Then Apriori algorithm was used to construct the model, and the association analysis was performed by using Clementine 12 to analyze the clinical drug use characteristics of Shenxiong glucose injection in the real world. A total of 411 kinds of Western medicines and 110 kinds of traditional Chinese medicines were included in 784 cases of drug combination. In the drug combination, aspirin had the highest frequency in Western medicine, which was used in 515 cases (65.69%); Ginkgo biloba extract had the highest frequency in Chinese medicine, which was used in 121 cases (15.43%). Atorvastatin+aspirin (association rules of 10.15%) was the most common Western medicine pairs; atorvastatin+clopidogrel+aspirin (association support 5.56%) was the most common triple Western medicine therapy, often combined with antibiotics and blood stasis drugs in use. Results showed that Shenxiong glucose injection was often combined with antiplatelet drugs and blood stasis drugs in the treatment of ischemic cerebrovascular disease clinically, contributing to the enhancement of platelet aggregation and blood stasis. The incompatibility of combined application of drugs shall be noted to ensure the clinical medication safety and efficacy of the combined drug use.

• Authors: Gui-Qian Wang, Yan-Ming Xie, Huan Liu, Yin Zhang, Ping-Ping Jia, Yan Zhuang
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 42 Issue 14 Pg. 2808-2813 (Jul 2017) ISSN: 1001-5302 [Print] China
• PMID: 29098842 (Publication Type: Journal Article, Multicenter Study)
• Copyright: Copyright© by the Chinese Pharmaceutical Association.

Chemical References

• Drugs, Chinese Herbal
• Plant Extracts
• shenxiong glucose
• Ginkgo biloba extract
• Atorvastatin
• Clopidogrel
• Aspirin

Topics

• Aspirin (therapeutic use)
• Atorvastatin (therapeutic use)
• Cerebrovascular Disorders (drug therapy)
• China
• Clopidogrel (therapeutic use)
• Drug Therapy, Combination
• Drugs, Chinese Herbal (therapeutic use)
• Ginkgo biloba
• Hospital Information Systems
• Humans
• Ischemia (drug therapy)
• Medicine, Chinese Traditional
• Plant Extracts (therapeutic use)