Different EGFR gene mutations in two patients with synchronous multiple lung cancers: A case report.

Abstract

Routine clinical and pathological evaluations to determine the relationship between different lesions are often not completely conclusive. Interestingly, detailed genetic analysis of tumor samples may provide important additional information and identify second primary lung cancers. In the present study, we report cases of two synchronous lung adenocarcinomas composed of two distinct pathological subtypes with different EGFR gene mutations: a homozygous deletion in exon 19 of the papillary adenocarcinoma subtype and a point mutation of L858R in exon 21 of the tubular adenocarcinoma. The present report highlights the clinical importance of molecular cancer biomarkers to guide management decisions in cases involving multiple lung tumors.

• Authors: Hiroki Sakai, Hisashi Saji, Hiroyuki Kimura, Masataka Tsuda, Yoichi Wakiyama, Tomoyuki Miyazawa, Hideki Marushima, Koji Kojima, Masahiro Hoshikawa, Masayuki Takagi, Haruhiko Nakamura
• Journal: Thoracic cancer (Thorac Cancer) Vol. 9 Issue 1 Pg. 189-192 (01 2018) ISSN: 1759-7714 [Electronic] Singapore
• PMID: 29090842 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2017 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.

Chemical References

• ErbB Receptors

Topics

• Aged
• ErbB Receptors (genetics)
• Female
• Humans
• Lung Neoplasms (genetics, pathology)
• Male
• Mutation