Objective: To observe the therapeutic efficacy of
alanyl glutamine injection on patients with gastrointestinal function obstacle caused by severe
phorate poisoning. Methods: A total of 80 eligible patients with gastrointestinal function obstacle caused by severe
phorate poisoning were randomly divided into the control group (n=40) and treatment group (n=40) . The control group was treated with the conventional
therapy, which included forbidden diet,
atropine,
pralidoxime iodide, anti-inflammatory,
albumin infusion, ω-3
fish oil fat
emulsion, protection of organs function, blood perfusion, and Fat
Emulsion,
Amino Acids (17) and
Glucose Injection. The treatment group was treated with
alanyl glutamine injection plus the conventional
therapy. To observe the time of recovering to normal of gastrointestinal function between the two groups, compared the AChE activity and changes of
prealbumin,
albumin and total
protein of the two groups respectively. Furthermore, the total
atropine dosage, the total
pralidoxime iodide dosage and ICU stay time between the two groups were also compared. Results: The gastrointestinal function recovery time of patients in the treatment group was less than the control group, the difference was statistically significant (P<0.05) . From the third day of treatment, the serum
cholinesterase activity of the treatment group was higher than the control group, the difference was statistically significant (P<0.05) . On the 5th day and 10th day of the treatment, the
prealbumin,
albumin and total
protein of the treatment group were significantly higher than these indexes of the control group in the same period, the difference were statistically significant (P<0.05) . The total
atropine dosage, the total
pralidoxime iodide dosage and ICU stay time in the treatment group were lower than the control group, the difference were statistically significant (P<0.05) . Conclusion:
Alanyl glutamine injection has a great
therapeutic effect for gastrointestinal function obstacle patients caused by severe
phorate poisoning.