Reversal of neuroleptic-induced catalepsy by novel aryl-piperazine anxiolytic drugs.

Abstract

The novel anxiolytic drug, buspirone, reverses catalepsy induced by haloperidol. A series of aryl-piperazine analogues of buspirone and other 5-hydroxytryptaminergic agonists were tested for their ability to reverse haloperidol induced catalepsy. Those drugs with strong affinity for 5-hydroxytryptamine1a receptors were able to reverse catalepsy. Drugs with affinity for other 5-HT receptors or weak affinity were ineffective. However, inhibition of postsynaptic 5-HT receptors neither inhibited nor potentiated reversal of catalepsy and leaves open the question as to the site or mechanism for this effect.

• Authors: B A McMillen, S M Scott, E A Davanzo
• Journal: The Journal of pharmacy and pharmacology (J Pharm Pharmacol) Vol. 40 Issue 12 Pg. 885-7 (Dec 1988) ISSN: 0022-3573 [Print] England
• PMID: 2907585 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Anxiety Agents
• Antipsychotic Agents
• Piperazines
• Morphine
• Pindolol
• Haloperidol
• Methysergide

Topics

• Animals
• Anti-Anxiety Agents (pharmacology)
• Antipsychotic Agents (pharmacology)
• Catalepsy (chemically induced, drug therapy)
• Drug Interactions
• Haloperidol (pharmacology)
• Male
• Methysergide (pharmacology)
• Morphine (pharmacology)
• Pindolol (pharmacology)
• Piperazines (pharmacology)
• Rats