Chemotherapy of experimental (murine) Clostridium perfringens type A gas gangrene.

Abstract

Five antimicrobial drugs (ciprofloxacin, clindamycin, imipenem, penicillin G, and rifampin) were examined for therapeutic efficacy in a murine model gas gangrene due to Clostridium perfringens type A, following infection with large bacterial inocula. Imipenem was effective against all 6 strains of C. perfringens; conversely, penicillin G failed against these 6 strains. Ciprofloxacin, clindamycin, and rifampin occupied intermediate positions.

• Authors: W H Traub
• Journal: Chemotherapy (Chemotherapy) Vol. 34 Issue 6 Pg. 472-7 ( 1988) ISSN: 0009-3157 [Print] Switzerland
• PMID: 2907452 (Publication Type: Journal Article)

Chemical References

• Clindamycin
• Ciprofloxacin
• Imipenem
• Penicillin G
• Rifampin

Topics

• Animals
• Ciprofloxacin (pharmacology)
• Clindamycin (pharmacology)
• Clostridium perfringens (drug effects)
• Disease Models, Animal
• Gas Gangrene (drug therapy)
• Imipenem (pharmacology)
• Mice
• Microbial Sensitivity Tests
• Penicillin G (pharmacology)
• Rifampin (pharmacology)