Abstract |
High levels of naturally occurring IgG antibodies to mucin 1 (MUC1), a membrane-bound glycoprotein that is overexpressed in patients with breast cancer, are associated with good prognosis. This suggests that endogenous anti-MUC1 antibodies have a protective effect and, through antibody-mediated host immunosurveillance mechanisms, might contribute to a cancer-free state. To test this possibility, we characterized a large number of multiethnic patients with breast cancer and matched controls for IgG antibodies to MUC1. We also aimed to determine whether the magnitude of anti-MUC1 antibody responsiveness was associated with particular immunoglobulin GM (γ marker), KM (κ marker), and Fcγ receptors (FcγR) genotypes. After adjusting for the confounding variables in a multivariate analysis, we found no significant difference in the levels of anti-MUC1 IgG antibodies between patients and cancer-free controls. However, in patients and controls, particular GM, KM, and FcγR genotypes-individually or epistatically-were significantly associated with the levels of anti-MUC1 IgG antibodies in a racially restricted manner. These findings, if confirmed in an independent investigation, could help identify individuals most likely to benefit from a MUC1-based therapeutic or prophylactic vaccine for MUC1-overexpressing malignancies.
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Authors | Janardan P Pandey, Aryan M Namboodiri, Bethany Wolf, Motoki Iwasaki, Yoshio Kasuga, Gerson S Hamada, Shoichiro Tsugane |
Journal | Immunobiology
(Immunobiology)
Vol. 223
Issue 2
Pg. 178-182
(02 2018)
ISSN: 1878-3279 [Electronic] Netherlands |
PMID | 29074302
(Publication Type: Journal Article)
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Copyright | Copyright © 2017 Elsevier GmbH. All rights reserved. |
Chemical References |
- Immunoglobulins
- Mucin-1
- Receptors, IgG
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Topics |
- Antibody Formation
- Brazil
(epidemiology)
- Breast Neoplasms
(epidemiology, immunology)
- Cohort Studies
- Ethnicity
- Female
- Genotype
- Humans
- Immunoglobulins
(blood, genetics)
- Immunologic Surveillance
- Japan
(epidemiology)
- Mucin-1
(immunology)
- Multivariate Analysis
- Racial Groups
- Receptors, IgG
(genetics)
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