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Endogenous antibody responses to mucin 1 in a large multiethnic cohort of patients with breast cancer and healthy controls: Role of immunoglobulin and Fcγ receptor genes.

Abstract
High levels of naturally occurring IgG antibodies to mucin 1 (MUC1), a membrane-bound glycoprotein that is overexpressed in patients with breast cancer, are associated with good prognosis. This suggests that endogenous anti-MUC1 antibodies have a protective effect and, through antibody-mediated host immunosurveillance mechanisms, might contribute to a cancer-free state. To test this possibility, we characterized a large number of multiethnic patients with breast cancer and matched controls for IgG antibodies to MUC1. We also aimed to determine whether the magnitude of anti-MUC1 antibody responsiveness was associated with particular immunoglobulin GM (γ marker), KM (κ marker), and Fcγ receptors (FcγR) genotypes. After adjusting for the confounding variables in a multivariate analysis, we found no significant difference in the levels of anti-MUC1 IgG antibodies between patients and cancer-free controls. However, in patients and controls, particular GM, KM, and FcγR genotypes-individually or epistatically-were significantly associated with the levels of anti-MUC1 IgG antibodies in a racially restricted manner. These findings, if confirmed in an independent investigation, could help identify individuals most likely to benefit from a MUC1-based therapeutic or prophylactic vaccine for MUC1-overexpressing malignancies.
AuthorsJanardan P Pandey, Aryan M Namboodiri, Bethany Wolf, Motoki Iwasaki, Yoshio Kasuga, Gerson S Hamada, Shoichiro Tsugane
JournalImmunobiology (Immunobiology) Vol. 223 Issue 2 Pg. 178-182 (02 2018) ISSN: 1878-3279 [Electronic] Netherlands
PMID29074302 (Publication Type: Journal Article)
CopyrightCopyright © 2017 Elsevier GmbH. All rights reserved.
Chemical References
  • Immunoglobulins
  • Mucin-1
  • Receptors, IgG
Topics
  • Antibody Formation
  • Brazil (epidemiology)
  • Breast Neoplasms (epidemiology, immunology)
  • Cohort Studies
  • Ethnicity
  • Female
  • Genotype
  • Humans
  • Immunoglobulins (blood, genetics)
  • Immunologic Surveillance
  • Japan (epidemiology)
  • Mucin-1 (immunology)
  • Multivariate Analysis
  • Racial Groups
  • Receptors, IgG (genetics)

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