The Occurrence of Antibodies Against Gluten in Children with Autism Spectrum Disorders Does Not Correlate with Serological Markers of Impaired Intestinal Permeability.

Abstract	There is evidence that children with autism spectrum disorders (ASDs) display an increased immune reactivity against gluten, which is supposed to be the effect of intestinal barrier abnormalities. The aim of study was to evaluate the relation of antibody induced by gluten to zonulin and intestinal fatty acid binding proteins (I-FABP), that is, serological markers of an impaired gut barrier. The study included 77 patients with ASDs. Zonulin, I-FABP, celiac-specific antibodies, anti-gliadin antibodies (AGA), and antibodies against neural transglutaminase 6 (TG6) of immunoglobulin (Ig) A and IgG classes were detected in sera. Celiac-specific antibodies were negative in all ASD children, four children (5.2%) had positive anti-TG6 antibodies, and increased AGA-IgG production was found in 21 patients (27.3%). Mean levels of zonulin and I-FABP in ASD patients were similar to those found in healthy controls and revealed a negative correlation with age, whereas regression analysis revealed a significant positive relationship between antibody production and the age. Serum concentrations of zonulin and I-FABP showed no statistically significant association with antibody positivity. An increased production of antibodies related to gliadin and neural TG6 in ASD children is not related to serological markers of an impaired intestinal barrier.
Authors	Jan Józefczuk, Ewa Konopka, Joanna Beata Bierła, Ilona Trojanowska, Agnieszka Sowińska, Rafał Czarnecki, Lucjan Sobol, Paweł Józefczuk, Weronika Surdy, Bożena Cukrowska
Journal	Journal of medicinal food (J Med Food) Vol. 21 Issue 2 Pg. 181-187 (Feb 2018) ISSN: 1557-7600 [Electronic] United States
PMID	29072974 (Publication Type: Journal Article)
Chemical References	Antibodies Biomarkers FABP2 protein, human Fatty Acid-Binding Proteins Haptoglobins Protein Precursors zonulin Glutens Cholera Toxin
Topics	Adolescent Antibodies (blood) Autism Spectrum Disorder (blood, immunology, metabolism) Biomarkers (blood) Child Child, Preschool Cholera Toxin (immunology) Fatty Acid-Binding Proteins (immunology) Female Glutens (immunology) Haptoglobins Humans Intestinal Mucosa (metabolism) Male Permeability Protein Precursors

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