Abstract |
We describe a group of psychotic patients who became worse early in the course of neuroleptic treatment. Characteristics of this group were: predominantly female sex, relatively brief onset, family history of affective disorder, hypomotoric presentation, and severe neuroleptic side effects. We propose that some patients with affective psychoses are uniquely susceptible to profound blockade of the nigrostriatal dopaminergic system by neuroleptics.
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Authors | M B Bowers Jr, M E Swigar |
Journal | Journal of clinical psychopharmacology
(J Clin Psychopharmacol)
Vol. 8
Issue 6
Pg. 417-21
(Dec 1988)
ISSN: 0271-0749 [Print] United States |
PMID | 2906948
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antipsychotic Agents
- Benztropine
- Thiothixene
- Haloperidol
- Chlorpromazine
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Topics |
- Adolescent
- Adult
- Antipsychotic Agents
(adverse effects, therapeutic use)
- Benztropine
(therapeutic use)
- Chlorpromazine
(adverse effects)
- Dyskinesia, Drug-Induced
(etiology)
- Female
- Haloperidol
(adverse effects)
- Humans
- Male
- Psychoses, Substance-Induced
(etiology)
- Psychotic Disorders
(drug therapy)
- Thiothixene
(adverse effects)
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