Double-blind comparison of 3-day versus 7-day treatment with norfloxacin in symptomatic urinary tract infections. The Inter-Nordic Urinary Tract Infection Study Group.

Abstract

The therapeutic efficacy and safety of norfloxacin 400 mg twice daily for 3 or 7 days was compared in a double-blind randomized multiclinic study including 485 female general practice patients with uncomplicated symptomatic lower urinary tract infections. 373 patients were considered valid for efficacy, 193 in the 3-day treatment group and 180 in the 7-day treatment group. The short-term efficacy (elimination of significant bacteriuria 3-13 days post-treatment) was 93.8% and 96.6% in the 3 and 7-day treatment groups, respectively, and the accumulated efficacy (elimination of significant bacteriuria 3 days post-treatment up until 45 days after the first dose) 81.3% and 91.7%, respectively (p less than 0.004). The median time to disappearance of symptoms was 3 days in both groups. Norfloxacin was well tolerated in both treatment groups.

• Journal: Scandinavian journal of infectious diseases (Scand J Infect Dis) Vol. 20 Issue 6 Pg. 619-24 ( 1988) ISSN: 0036-5548 [Print] England
• PMID: 2906171 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Norfloxacin

Topics

• Bacteriuria
• Double-Blind Method
• Drug Administration Schedule
• Female
• Humans
• Middle Aged
• Norfloxacin (administration & dosage, adverse effects, therapeutic use)
• Random Allocation
• Time Factors
• Urinary Tract Infections (drug therapy)