Abstract | AIMS: METHODS AND RESULTS: We compared clinical characteristics and treatment approaches between patients with or without a history of COPD, before and after 1:2 propensity matching (for age, sex, geographical region, income level, and ethnic group) in 5232 prospectively recruited patients with HF and reduced ejection fraction (HFrEF, <40%) from 11 Asian regions (Northeast Asia: South Korea, Japan, Taiwan, Hong Kong, and China; South Asia: India; Southeast Asia: Thailand, Malaysia, Philippines, Indonesia, and Singapore). Among the 5232 patients with HFrEF, a history of COPD was present in 8.3% (n = 434), with significant variation in geography (11.0% in Northeast Asia vs. 4.7% in South Asia), regional income level (9.7% in high income vs. 5.8% in low income), and ethnicity (17.0% in Filipinos vs. 5.2% in Indians) (all P < 0.05). Use of mineralocorticoid receptor antagonists and diuretics was similar between groups, while usage of all β-blockers was lower in the COPD group than in the non- COPD group in the overall (66.3% vs. 79.9%) and propensity-matched cohorts (66.3% vs. 81.7%) (all P < 0.05). A striking exception was the Japanese cohort in which β-blocker use was high in COPD and non- COPD patients (95.2% vs. 91.2%). CONCLUSIONS: The prevalence of COPD in HFrEF varied across Asia and was related to underuse of β-blockers, except in Japan.
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Authors | Yoshiaki Kubota, Wan Ting Tay, Kuniya Asai, Koji Murai, Ikutaro Nakajima, Nobuhisa Hagiwara, Takanori Ikeda, Takashi Kurita, Tiew-Hwa Katherine Teng, Inder Anand, Carolyn S P Lam, Wataru Shimizu, ASIA-HF Study investigators |
Journal | ESC heart failure
(ESC Heart Fail)
Vol. 5
Issue 2
Pg. 297-305
(04 2018)
ISSN: 2055-5822 [Electronic] England |
PMID | 29055972
(Publication Type: Journal Article, Multicenter Study, Observational Study, Research Support, Non-U.S. Gov't)
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Copyright | © 2017 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology. |
Chemical References |
- Adrenergic beta-Antagonists
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Topics |
- Adrenergic beta-Antagonists
(therapeutic use)
- Asia, Southeastern
(epidemiology)
- Comorbidity
- Female
- Follow-Up Studies
- Heart Failure
(drug therapy, epidemiology, physiopathology)
- Humans
- Male
- Middle Aged
- Prognosis
- Prospective Studies
- Pulmonary Disease, Chronic Obstructive
(drug therapy, epidemiology)
- Stroke Volume
(physiology)
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