Graves' disease of the beta cell: glucose dysregulation due to islet-cell stimulating antibodies.

Abstract

The immunoglobulin fractions of serum from patients with spontaneous hyperinsulinaemic hypoglycaemia and others with type 1 diabetes stimulated insulin release both in islet-cell cultures and in vivo in rats. Serum from patients with type 2 diabetes, which is not an autoimmune disease, did not stimulate insulin release. The discovery of islet-cell-stimulating antibodies (ICSTA) completes for the islet the triad of autoantibodies (anticytoplasmic, antiproduct, and antireceptor) previously described in autoimmune thyroid disease. ICSTA may be important modulators of islet-cell secretion in man.

• Authors: T J Wilkin, P Hammonds, I Mirza, A J Bone, K Webster
• Journal: Lancet (London, England) (Lancet) Vol. 2 Issue 8621 Pg. 1155-8 (Nov 19 1988) ISSN: 0140-6736 [Print] England
• PMID: 2903375 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Autoantibodies
• Blood Glucose
• Insulin
• Insulin Antibodies
• islet cell antibody
• islet-cell-stimulating antibodies

Topics

• Adolescent
• Adult
• Aged
• Animals
• Autoantibodies (immunology)
• Blood Glucose (analysis)
• Cell Line
• Child
• Child, Preschool
• Cricetinae
• Diabetes Mellitus, Type 1 (immunology)
• Female
• Graves Disease (immunology)
• Humans
• Hyperinsulinism (immunology)
• Hypoglycemia (immunology)
• Insulin (blood, metabolism)
• Insulin Antibodies (immunology)
• Insulin Secretion
• Islets of Langerhans (immunology)
• Male
• Middle Aged
• Rats
• Rats, Inbred Strains