The use of respiratory stimulants in organophosphates' intoxication.

Abstract

1. Depression of the respiratory center causing acute respiratory insufficiency is the main cause of death in acute poisoning with organophosphates (OP) 2. Various authors recommend the use of respiratory stimulants as an adjuvant to the usual therapeutic arsenal. 3. This survey of the literature was undertaken in order to explore the theoretical basis for this therapeutic attitude and to critically assess its usefulness. 4. The conclusion of this review is that respiratory stimulants should not be used in the treatment of acute organophosphates' intoxication in human beings.

• Authors: Y Lerman, H Gutman
• Journal: Medical hypotheses (Med Hypotheses) Vol. 26 Issue 4 Pg. 267-9 (Aug 1988) ISSN: 0306-9877 [Print] United States
• PMID: 2902508 (Publication Type: Journal Article, Review)

Chemical References

• Central Nervous System Stimulants

Topics

• Central Nervous System Stimulants (adverse effects, therapeutic use)
• Humans
• Organophosphate Poisoning
• Respiratory Insufficiency (chemically induced, drug therapy)