Abstract |
Carcinoid syndrome produces flushing, bronchoconstriction and gastrointestinal hypermotility secondary to serotonin, histamine, bradykinin and prostaglandin release. A variety of drugs, foods and anaesthetic agents may provoke this syndrome. Under anaesthesia, the flushing produced may be associated with acute hypotension and cardiovascular collapse; this phenomenon is called a carcinoid crisis. Recently, somatostatin analogue has been used successfully to treat intraoperative carcinoid crisis. In this report, we present a 66-year-old lady with carcinoid syndrome who was pre-treated with 50 micrograms somatostatin analogue IV and IM prior to surgical manipulation. The anaesthetic course was relatively uneventful and the patient did well postoperatively.
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Authors | W C Parris, J A Oates, J Kambam, R Shmerling, J F Sawyers |
Journal | Canadian journal of anaesthesia = Journal canadien d'anesthesie
(Can J Anaesth)
Vol. 35
Issue 4
Pg. 413-6
(Jul 1988)
ISSN: 0832-610X [Print] United States |
PMID | 2900085
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Aged
- Anesthesia, General
- Anesthesia, Inhalation
- Anesthesia, Intravenous
- Female
- Humans
- Ileal Neoplasms
(surgery)
- Malignant Carcinoid Syndrome
(physiopathology, surgery)
- Ovarian Neoplasms
(surgery)
- Premedication
- Somatostatin
(administration & dosage, analogs & derivatives)
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