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Pre-treatment with somatostatin in the anaesthetic management of a patient with carcinoid syndrome.

Abstract
Carcinoid syndrome produces flushing, bronchoconstriction and gastrointestinal hypermotility secondary to serotonin, histamine, bradykinin and prostaglandin release. A variety of drugs, foods and anaesthetic agents may provoke this syndrome. Under anaesthesia, the flushing produced may be associated with acute hypotension and cardiovascular collapse; this phenomenon is called a carcinoid crisis. Recently, somatostatin analogue has been used successfully to treat intraoperative carcinoid crisis. In this report, we present a 66-year-old lady with carcinoid syndrome who was pre-treated with 50 micrograms somatostatin analogue IV and IM prior to surgical manipulation. The anaesthetic course was relatively uneventful and the patient did well postoperatively.
AuthorsW C Parris, J A Oates, J Kambam, R Shmerling, J F Sawyers
JournalCanadian journal of anaesthesia = Journal canadien d'anesthesie (Can J Anaesth) Vol. 35 Issue 4 Pg. 413-6 (Jul 1988) ISSN: 0832-610X [Print] United States
PMID2900085 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Somatostatin
Topics
  • Aged
  • Anesthesia, General
  • Anesthesia, Inhalation
  • Anesthesia, Intravenous
  • Female
  • Humans
  • Ileal Neoplasms (surgery)
  • Malignant Carcinoid Syndrome (physiopathology, surgery)
  • Ovarian Neoplasms (surgery)
  • Premedication
  • Somatostatin (administration & dosage, analogs & derivatives)

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