| Abstract | The class I and class II HLA serologically defined antigens and DQ alpha and DX alpha restriction fragment length polymorphism (RFLP) in 23 patients with linear IgA disease (LAD) were determined and their frequencies compared with those in a group of patients with dermatitis herpetiformis (DH) and healthy controls. In LAD there was a significant increase in HLA-B8 and DR3 and a larger increase in the DQw1-DR2/DRw6 related DQ alpha 6.2 kb and 6.8 kb RFLP. In DH there was a significantly increased frequency of HLA-A1, B8, DR3, and DQw2 with a concomitant increase in the DR3-DQw2 related DQ alpha 4.6 kb RFLP. The difference in DR3 frequencies and the increased frequency of DQw1 rather than DQw2 in LAD indicates that different susceptibility genes operate in the two diseases. |
| Authors | J A Sachs, J Leonard, J Awad, D McCloskey, H Festenstein, G A Hitman, L Fry
(Affiliation: Department of Immunology, London Hospital Medical College, U.K.)
|
| Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 118
Issue 6
Pg. 759-64
(Jun 1988)
ISSN: 0007-0963 ENGLAND |
| PMID | 2900020
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- HLA-DQ Antigens
- HLA-DQ1
- HLA-DR Antigens
- HLA-DR2 Antigen
- HLA-DR3 Antigen
- HLA-DR6 Antigen
- Immunoglobulin A
|
| Topics |
- Dermatitis Herpetiformis
(blood, immunology, metabolism)
- Female
- HLA-DQ Antigens
(analysis)
- HLA-DR Antigens
(analysis)
- HLA-DR2 Antigen
- HLA-DR3 Antigen
- HLA-DR6 Antigen
- Histocompatibility Testing
- Humans
- Immunoglobulin A
(analysis)
- Male
- Polymorphism, Restriction Fragment Length
- Skin Diseases, Vesiculobullous
(blood, immunology, metabolism)
|
