Intracerebral SCH 23390 and catalepsy in the rat.

Abstract	Stereotaxic injection of SCH 23390 (D-1 antagonist), but not water or ritanserin (5-HT antagonist), into all parts of the caudate-putamen, elicited an immediate and often long-lasting catalepsy in 79% of rats. Similar results were obtained with SCH 23390 delivered into the nucleus accumbens and globus pallidus, but not into a variety of other brain sites. The results support the idea that SCH 23390-induced catalepsy is related to the occlusion of dopamine D-1 receptors in the forebrain, particularly the striatum, although the topography of the catalepsy evoked by intrastriatal SCH 23390 did not match the distribution of D-1 sites labelled in autoradiographic studies.
Authors	G H Fletcher, M S Starr
Journal	European journal of pharmacology (Eur J Pharmacol) Vol. 149 Issue 1-2 Pg. 175-8 (Apr 27 1988) ISSN: 0014-2999 [Print] Netherlands
PMID	2899514 (Publication Type: Journal Article)
Chemical References	Antipsychotic Agents Benzazepines
Topics	Animals Antipsychotic Agents (administration & dosage, pharmacology) Benzazepines (administration & dosage, pharmacology) Brain Catalepsy (chemically induced) Corpus Striatum Female Injections Injections, Subcutaneous Rats Rats, Inbred Strains

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