Utilization patterns of systemic corticosteroid use for chronic rhinosinusitis.

Abstract

OBJECTIVE:

We sought to characterize the utilization pattern and factors associated with use of systemic corticosteroids for CRS.

METHODS:

This was a cross-sectional study of 236 participants with CRS who were prospectively recruited. Participants reported the number of CRS-related oral corticosteroid courses taken in the last year. Baseline CRS symptomatology was measured using the 22-item Sinonasal Outcome Test (SNOT-22) and SNOT-22 sleep, nasal, otologic/facial pain and emotional subdomain scores. Clinical and demographic characteristics were also collected. Association was determined between patient characteristics and oral corticosteroid use in the last year for CRS.

RESULTS:

Sleep (p = .026), nasal (p < .001) and otologic/facial pain (p = .022) SNOT-22 subdomain scores, and nasal polyps (p = .007) were associated with CRS-related oral corticosteroid use. In study participants without polyps, past CRS-related oral corticosteroid use was associated with sleep (adjusted OR = 1.56, 95%CI: 1.01-2.40, p = .043), otologic/facial pain (adjusted OR = 1.65, 95%CI: 1.09-2.51, p = .019) and nasal subdomain scores (adjusted OR = 1.59, 95%CI: 1.01-2.51, p = .047). In study participants with polyps, past CRS-related oral corticosteroid use was only associated with the nasal subdomain score (adjusted OR = 2.20, 95%CI: 1.40-3.45, p = .001).

CONCLUSIONS:

Past CRS-related oral corticosteroid use was associated with increased baseline severity of specific symptoms, which were different depending on the presence of polyps.

• Authors: Stacey T Gray, Katie M Phillips, Lloyd P Hoehle, Allen L Feng, Alisa Yamasaki, David S Caradonna, Ahmad R Sedaghat
• Journal: Acta oto-laryngologica (Acta Otolaryngol) Vol. 138 Issue 2 Pg. 153-158 (Feb 2018) ISSN: 1651-2251 [Electronic] England
• PMID: 28990841 (Publication Type: Journal Article)

Chemical References

• Adrenal Cortex Hormones

Topics

• Administration, Oral
• Adrenal Cortex Hormones (therapeutic use)
• Adult
• Chronic Disease
• Cross-Sectional Studies
• Female
• Humans
• Male
• Middle Aged
• Rhinitis (drug therapy)
• Severity of Illness Index
• Sinusitis (drug therapy)