Antineoplastic activity of two taxol derivatives on an ovarian tumor xenografted into nude mice.

Abstract

In order to compare the antineoplastic activities of taxol A, taxol B, a mixture of the two (taxol A 72%) and vinblastine, a human ovarian tumor serially transplanted into 104 female athymic mice was used. In the first experiment (11th passage), the antineoplastic activities of taxol A, taxol B and the mixture taxol AB were tested. The same dose was used in each case (12.5 mg/kg i.e. 1/20 of the evaluated LD50 value). It was administered subcutaneously for 5 consecutive days. Three courses of treatment were performed, with 2 rest periods of 1 week in between. All the taxol derivatives produced a statistically significant delay in the tumor growth. However, taxol B had the lowest chemotherapeutic response. In the second experiment (18th passage), different dose levels were administered (mixture 12.5 mg/kg/day x 4 - taxol A 8.8. mg/kg/day x 4 - taxol B 3.5 mg/kg/day x 4 - vinblastine 0.5 mg/kg/day x 2). For all the taxol derivatives 4 treatment courses with 3 rest periods of 4 days were used, and for vinblastine 4 treatment courses with 3 rest periods of 1 week. At the end of the second experiment, vinblastine, taxol A and a mixture of the two showed similar significant activity, whereas no objective antitumor response was observed following the taxol B treatment at the dose level chosen. The experimental results obtained clearly demonstrate that, in the taxane system, the greatest degree of antineoplastic activity can be attributed to taxol A.

• Authors: J Riondel, M Jacrot, M F Nissou, F Picot, H Bériel, C Mouriquand, P Potier
• Journal: Anticancer research (Anticancer Res) 1988 May-Jun Vol. 8 Issue 3 Pg. 387-90 ISSN: 0250-7005 [Print] Greece
• PMID: 2898915 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkaloids
• Antineoplastic Agents, Phytogenic
• Taxoids
• Vinblastine
• cephalomannine
• Paclitaxel

Topics

• Alkaloids (administration & dosage, therapeutic use)
• Animals
• Antineoplastic Agents, Phytogenic (administration & dosage, therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cystadenocarcinoma (drug therapy, pathology)
• Drug Screening Assays, Antitumor
• Female
• Humans
• Mice
• Mice, Nude
• Neoplasm Transplantation
• Ovarian Neoplasms (drug therapy, pathology)
• Paclitaxel
• Taxoids
• Transplantation, Heterologous
• Vinblastine (administration & dosage)