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Long-term use of somatostatin analogue SMS 201-995 in the treatment of hypoglycaemia due to nesidioblastosis.

Abstract
An infant presented with hypoglycaemia secondary to nesidioblastosis. Subtotal pancreatectomy failed to prevent recurrent post-operative hypoglycaemia. Subcutaneous somatostatin analogue (SMS 201-995) was shown to increase the blood concentrations of glucose and B-hydroxybutyrate while lowering serum insulin levels. Regular use of somatostatin analogue was helpful in long term management without causing significant side effects.
AuthorsD C Wilson, D J Carson, R J Quinn
JournalActa paediatrica Scandinavica (Acta Paediatr Scand) Vol. 77 Issue 3 Pg. 467-70 (May 1988) ISSN: 0001-656X [Print] Sweden
PMID2898862 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Somatostatin
  • Octreotide
Topics
  • Female
  • Humans
  • Hypoglycemia (drug therapy, etiology)
  • Infant
  • Infant, Newborn
  • Injections, Subcutaneous
  • Octreotide
  • Pancreatectomy
  • Pancreatic Diseases (complications, therapy)
  • Somatostatin (administration & dosage, analogs & derivatives)
  • Time Factors

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