[Studies on the clinical significance concerning the changes in serum pepsinogen-I and gastrin levels in aged patients with chronic gastritis].

Abstract

Of 86 cases of aged patients with chronic gastritis treated with Trimebutine or Flutazolam, we evaluated the changes of serum pepsinogen-I and gastrin levels in their clinical courses from the points of the correlation with severity of chronic gastritis, aging phenomenon and the changes of symptom and endoscopic findings. In order to elucidate the multidimensional interrelation among these items, we used Hayashi's quantification theory II as a conventional analysis method. In aged patients, generally, although the serum gastrin levels were rather high compared with younger generation, the serum pepsinogen-I levels were consistently low throughout their clinical courses. There were some correlation between the levels of serum gastrin and the severity of chronic gastritis. When the drugs were effective on improving the condition of the disease, the level of gastrin revealed gradual decrease. These changes of gastrin were more typical in patients treated with Trimebutine.

• Authors: Y Hamada, K Kamiya, M Koyama, M Asaka, T Matsushima, T Myazaki, T Kamiya
• Journal: [Hokkaido igaku zasshi] The Hokkaido journal of medical science (Hokkaido Igaku Zasshi) Vol. 63 Issue 2 Pg. 178-85 (Mar 1988) ISSN: 0367-6102 [Print] Japan
• PMID: 2898425 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Anxiety Agents
• Benzodiazepinones
• Gastrins
• Pepsinogens
• Benzodiazepines
• flutazolam
• Trimebutine

Topics

• Aged
• Anti-Anxiety Agents (therapeutic use)
• Benzodiazepines
• Benzodiazepinones (therapeutic use)
• Chronic Disease
• Female
• Gastrins (blood)
• Gastritis (blood, drug therapy)
• Humans
• Male
• Middle Aged
• Pepsinogens (blood)
• Trimebutine (therapeutic use)