Effects of D-(-)-aminophosphonovalerate on behavioral and histological changes induced by systemic kainic acid.

Abstract

In rats, the seizures induced by systemic kainic acid (KA) are followed by extensive neuronal damage, notably in the hippocampal region. We report that the specific N-methyl-D-aspartate (NMDA) receptor antagonist, D-(-)-aminophosphonovalerate (D(-)APV), given i.c.v. prior to or 2 h after i.p. KA injection markedly protected CA1 but not other hippocampal neurons against degeneration. In contrast, D(-)APV had no effect on KA-induced wet dog shakes or on behavioral seizures. We conclude that NMDA receptors participate in the neurotoxic but not in the behavioral effects of systemic KA.

• Authors: W Lason, J N Simpson, J F McGinty
• Journal: Neuroscience letters (Neurosci Lett) Vol. 87 Issue 1-2 Pg. 23-8 (Apr 22 1988) ISSN: 0304-3940 [Print] Ireland
• PMID: 2898113 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Receptors, N-Methyl-D-Aspartate
• Receptors, Neurotransmitter
• 2-Amino-5-phosphonovalerate
• Valine
• Kainic Acid

Topics

• 2-Amino-5-phosphonovalerate
• Animals
• Hippocampus (drug effects, pathology, physiopathology)
• Injections, Intraperitoneal
• Kainic Acid (toxicity)
• Male
• Rats
• Rats, Inbred Strains
• Receptors, N-Methyl-D-Aspartate
• Receptors, Neurotransmitter (drug effects, physiology)
• Seizures (chemically induced, physiopathology)
• Valine (analogs & derivatives, pharmacology)