[Characteristics of dimedrol, pipolfen and suprastin absorption from the small intestine of rats in systemic anaphylactic shock].

Abstract

It was shown by the in situ method that absorption of dimedrol, pipolphen and suprastine from the small intestine of the rats immunized parenterally with ovalbumin against the background of intravenous administration of the resolving dose of ovalbumin significantly decreased in connection with the formation in the immunized rats of antiovalbumin antibodies. Administration of euphylline simultaneously with the resolving dose of ovalbumin to the immunized rats partially normalized absorbability of all three drugs.

• Authors: K I Bender, A N Lutsevich, I N Lutsevich
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1988 Mar-Apr Vol. 51 Issue 2 Pg. 85-8 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Osobennosti vsasyvaniia dimedrola, pipol'fena i suprastina iz tonkoĭ kishki krysy pri sistemnom anafilakticheskom shoke.
• PMID: 2897935 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Ethylenediamines
• Histamine H1 Antagonists
• Aminophylline
• chloropyramine
• Diphenhydramine
• Ovalbumin
• Promethazine

Topics

• Aminophylline (pharmacology)
• Anaphylaxis (etiology, metabolism)
• Animals
• Diphenhydramine (pharmacokinetics)
• Dose-Response Relationship, Immunologic
• Ethylenediamines (pharmacokinetics)
• Histamine H1 Antagonists (pharmacokinetics)
• Immunization (methods)
• Intestinal Absorption (drug effects)
• Intestine, Small (drug effects, metabolism)
• Male
• Ovalbumin (administration & dosage, immunology)
• Passive Cutaneous Anaphylaxis (drug effects)
• Promethazine (pharmacokinetics)
• Rats