Abstract |
The efficacy and side effects of the oral H1-antihistamine, astemizole, were compared with those of nasal beclomethasone in 158 adult birch-pollen allergic hay fever patients. 148 patients completed the 5-week, controlled trial which took place in Stockholm, May 1986, during the birch pollen season. Daily pollen counts were found to be at a rather low level throughout the study period. The effect and tolerability of both drugs were found to be excellent, although beclomethasone reduced nasal symptoms ( sneezing, rhinorrhoea, blocked nose) significantly more effectively than astemizole. Eye symptoms were mild and equal in both groups. The results indicate that oral astemizole is an effective non-sedating antihistamine, though less so than nasal beclomethasone, in the treatment of nasal hay fever symptoms.
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Authors | P Salomonsson, L Gottberg, H Heilborn, K Norrlind, K O Pegelow |
Journal | Allergy
(Allergy)
Vol. 43
Issue 3
Pg. 214-8
(Apr 1988)
ISSN: 0105-4538 [Print] Denmark |
PMID | 2897804
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Benzimidazoles
- Histamine H1 Antagonists
- Astemizole
- Beclomethasone
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Topics |
- Administration, Oral
- Adolescent
- Adult
- Astemizole
- Beclomethasone
(adverse effects, therapeutic use)
- Benzimidazoles
(adverse effects, therapeutic use)
- Body Weight
(drug effects)
- Female
- Histamine H1 Antagonists
(therapeutic use)
- Humans
- Male
- Middle Aged
- Rhinitis, Allergic, Seasonal
(drug therapy)
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