ADALIMUMAB FOR ULCERATIVE COLITIS: RESULTS OF A BRAZILIAN MULTICENTER OBSERVATIONAL STUDY.

Abstract

BACKGROUND:

Adalimumab is a monoclonal antibody, tumor necrosis factor-alpha (TNFα) inhibitor that has efficacy for inducing and maintaining remission in moderate-to-severe ulcerative colitis. Real world studies with adalimumab in Latin American ulcerative colitis patients are scarce.

OBJECTIVE:

To assess the clinical remission rates in induction and maintenance with adalimumab therapy in ulcerative colitis.

METHODS:

Observational, multicenter and retrospective study on a case series of patients with moderate-to-severe ulcerative colitis under adalimumab therapy. The variables analyzed were: demographic data, previous infliximab status, concomitant drugs, the Montreal Classification, disease activity (Mayo score) at weeks 0, 8, 26 and 52, or until the last follow-up. Clinical remission was defined as a partial Mayo score ≤2 and Last observation carried forward (LOCF) and Non responder imputation (NRI) analysis were used.

RESULTS:

Thirty-six patients were included in the study. With LOCF analysis, remission rates at weeks 8, 26 e 52 were of 41.7%, 47.2% and 47.2%, respectively. With NRI analysis, remission rates at weeks 8, 26 and 52 were of 41.7%, 41.7% and 27.8%, respectively.

CONCLUSION:

Adalimumab was effective in the treatment of moderate-to-severe ulcerative colitis. Clinical remission was observed in approximately 40% of the patients at weeks 8 and 26, and in almost a quarter of the patients after 1 year of follow up.

• Authors: Patrícia Zacharias, Aderson Omar Mourão Cintra Damião, Antonio Carlos Moraes, Fábio Vieira Teixeira, Juliano Coelho Ludvig, Rodrigo Bremer Nones, Rogerio Saad-Hossne, Ligia Yukie Sassaki, Rosemary Pereira Lino da Silva, Luiza Facchin, Marcia Olandoski, Paulo Gustavo Kotze
• Journal: Arquivos de gastroenterologia (Arq Gastroenterol) Vol. 54 Issue 4 Pg. 321-327 (Dec 2017) ISSN: 1678-4219 [Electronic] Brazil
• PMID: 28977114 (Publication Type: Journal Article, Multicenter Study, Observational Study)

Chemical References

• Anti-Inflammatory Agents
• Antibodies, Monoclonal, Humanized
• Adalimumab

Topics

• Adalimumab (therapeutic use)
• Adolescent
• Adult
• Aged
• Anti-Inflammatory Agents (therapeutic use)
• Antibodies, Monoclonal, Humanized (therapeutic use)
• Colitis, Ulcerative (drug therapy)
• Female
• Humans
• Longitudinal Studies
• Male
• Middle Aged
• Retrospective Studies
• Severity of Illness Index
• Treatment Outcome
• Young Adult