Inhibition of the cataleptic effect of tetrahydrocannabinol by other constituents of Cannabis sativa L.

Abstract

Tetrahydrocannabinol (THC) induced catalepsy in mice, whereas a cannabis oil (6.68% w/w THC), four cannabinoids and a synthetic mixture did not. Cannabinol (CBN) and olivetol inhibited THC-induced catalepsy in the mornings and the evenings, but cannabidiol (CBD) exhibited this effect only in the evenings. A combination of CBN and CBD inhibited THC-induced catalepsy equal to that of CBN alone in the mornings, but this inhibition was greater than that produced by CBN alone in the evenings.

• Authors: E A Formukong, A T Evans, F J Evans
• Journal: The Journal of pharmacy and pharmacology (J Pharm Pharmacol) Vol. 40 Issue 2 Pg. 132-4 (Feb 1988) ISSN: 0022-3573 [Print] England
• PMID: 2897447 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cannabinoids
• Resorcinols
• olivetol
• Dronabinol

Topics

• Animals
• Cannabinoids (pharmacology)
• Cannabis (analysis)
• Catalepsy (chemically induced)
• Chromatography, Gas
• Dronabinol (antagonists & inhibitors, toxicity)
• Male
• Mice
• Resorcinols (pharmacology)