Effects of AN-132 and quinidine, antiarrhythmic agents, on plasma digoxin concentrations in rats.

Abstract

The effects of AN-132, 3-(diisopropylaminoethyl-amino)-2',6'-dimethylpropionanilide.2H 3PO4, on chloroform-induced arrhythmias and plasma digoxin concentrations have been compared with those of quinidine in rats. AN-132 (0.01-3 mg kg-1) administered orally significantly inhibited the incidence of cardiac arrhythmias in a dose-related fashion. A single dose of digoxin (1 mg kg-1) given orally for 7 consecutive days was followed, on day 8, orally by digoxin alone, or together with AN-132 (50, 100 and 200 mg kg-1) or quinidine (25 and 50 mg kg-1). The AUC0-24 and Cmax of plasma digoxin were enhanced significantly by co-administration of quinidine, but not by AN-132.

• Authors: K Sakai, T Yamazaki, Y Hinohara
• Journal: The Journal of pharmacy and pharmacology (J Pharm Pharmacol) Vol. 40 Issue 1 Pg. 68-9 (Jan 1988) ISSN: 0022-3573 [Print] England
• PMID: 2896782 (Publication Type: Journal Article)

Chemical References

• 3-(diisopropylaminoethylamino)-2',6'-dimethylpropionanilide, diphosphoric acid
• Anilides
• Anti-Arrhythmia Agents
• Ethylenediamines
• Digoxin
• Chloroform
• Quinidine

Topics

• Anilides (pharmacology)
• Animals
• Anti-Arrhythmia Agents (pharmacology)
• Arrhythmias, Cardiac (chemically induced, physiopathology)
• Chloroform
• Digoxin (blood, pharmacokinetics)
• Drug Interactions
• Ethylenediamines (pharmacology)
• Male
• Quinidine (pharmacology)
• Rats
• Rats, Inbred Strains