Effect of mifentidine on mepirizole-induced duodenal ulcer in the rat.

Abstract

The H2-receptor antagonists mifentidine, famotidine, cimetidine and ranitidine were examined for their ability to prevent the duodenal ulcer caused by mepirizole (250 mg/kg p.o.), a non-steroidal anti-inflammatory agent, in the conscious rat. All the compounds exerted a dose-related protective effect and on the basis of their ED50s, the following rank order of potency was found: mifentidine = famotidine greater than ranitidine greater than cimetidine. The antiulcer activity displayed by the H2-receptor antagonists evaluated in this model reflects their potency in inhibiting basal and stimulated gastric acid secretion in rat. The results of these studies indicate mifentidine as a potent anti-ulcer agent.

• Authors: A Brambilla, A Ghiorzi, A M De Paoli, A Giachetti
• Journal: Pharmacological research communications (Pharmacol Res Commun) Vol. 19 Issue 12 Pg. 877-85 (Dec 1987) ISSN: 0031-6989 [Print] United States
• PMID: 2896364 (Publication Type: Journal Article)

Chemical References

• Anti-Ulcer Agents
• Histamine H2 Antagonists
• Imidazoles
• Pyrazoles
• Thiazoles
• mifentidine
• Epirizole
• Famotidine
• Cimetidine
• Ranitidine

Topics

• Animals
• Anti-Ulcer Agents
• Cimetidine (pharmacology)
• Dose-Response Relationship, Drug
• Duodenal Ulcer (chemically induced, pathology, prevention & control)
• Duodenum (pathology)
• Epirizole (antagonists & inhibitors)
• Famotidine
• Female
• Histamine H2 Antagonists (pharmacology)
• Imidazoles (pharmacology)
• Intestinal Mucosa (pathology)
• Pyrazoles (antagonists & inhibitors)
• Ranitidine (pharmacology)
• Rats
• Rats, Inbred Strains
• Thiazoles (pharmacology)