Urinary excretion of D-glucaric acid in porphyria cutanea tarda.

Abstract

Twenty patients with porphyria cutanea tarda who had ingested no alcohol for at least 10 days before sampling were found to possess urinary D-glucaric acid levels similar to those of 30 clinically healthy controls. Correlation between urinary excretion of D-glucaric acid on the one hand and plasma or urinary porphyrin concentrations on the other was not statistically significant. These results suggest that the high urinary concentrations of D-glucaric acid found in porphyria cutanea tarda patients by Budillon et al. (Acta Hepato-Gastroenterol. 25 (1978) 267) may have been due to recent consumption of alcohol rather than to the porphyrin pathology.

• Authors: J C Tutor, A Lopez-Urrutia, M P Fernandez
• Journal: Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie (J Clin Chem Clin Biochem) Vol. 25 Issue 12 Pg. 855-8 (Dec 1987) ISSN: 0340-076X [Print] Germany
• PMID: 2895161 (Publication Type: Journal Article)

Chemical References

• Porphyrins
• Sugar Acids
• gamma-Glutamyltransferase
• Glucaric Acid

Topics

• Alcohol Drinking
• Glucaric Acid (urine)
• Humans
• Male
• Porphyrias (urine)
• Porphyrins (blood, urine)
• Skin Diseases (urine)
• Sugar Acids (urine)
• gamma-Glutamyltransferase (blood)