Abstract |
The effects of HSR-902, an antimuscarinic agent, on acute gastric mucosal lesions induced by various necrotizing agents, gastric mucus secretion and gastric HCO3- secretion in rats were compared with those of pirenzepine.2HCl ( pirenzepine), an antiulcer agent. 1) HSR-902 (10-100 mg/kg), given orally, dose-dependently prevented the gastric mucosal lesions induced by ethanol-HCl (60% ethanol in 150 mM HCl), aspirin-HCl (150 mg/kg of aspirin in 150 mM HCl), 0.6 N HCl and 0.2 N NaOH; and the cytoprotective effects of HSR-902 were almost equal or somewhat more potent than those of pirenzepine. 2) HSR-902 (30 mg/kg, p.o.), like pirenzepine, increased the alcian blue binding to gastric mucosa and both hexosamine and N-acetylneuramic acid in gastric juice and reversed the decrease of alcian blue binding to gastric mucosa in water-immersion stress. 3) HSR-902 (30 mg/kg, p.o.), unlike pirenzepine and atropine sulfate, increased the gastric HCO3- secretion in the pylorus-ligated preparations. 4) The cytoprotective effect of HSR-902 (30 mg/kg, p.o.), when examined using gastric mucosal lesion induced by aspirin-HCl, was not abolished by the pretreatment with indomethacin (10 mg/kg, s.c.) or N-ethylmaleimide (10 mg/kg, s.c.). 5) HSR-902 (30 mg/kg, p.o.) did not influence the gastric mucosal potential difference. These results suggest that HSR-902 is a promising drug for the treatment of gastritis and peptic ulcers.
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Authors | K Morikawa, T Aratani, F Mizutani, H Kato, Y Ito |
Journal | Nihon yakurigaku zasshi. Folia pharmacologica Japonica
(Nihon Yakurigaku Zasshi)
Vol. 90
Issue 5
Pg. 285-93
(Nov 1987)
ISSN: 0015-5691 [Print] Japan |
PMID | 2895054
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Bicarbonates
- Ganglionic Blockers
- Quinolizines
- Pirenzepine
- thiaton
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Topics |
- Animals
- Bicarbonates
(metabolism)
- Ganglionic Blockers
(pharmacology, therapeutic use)
- Gastric Mucosa
(metabolism, pathology)
- Male
- Pirenzepine
(pharmacology)
- Quinolizines
(pharmacology, therapeutic use)
- Rats
- Rats, Inbred Strains
- Stomach Ulcer
(drug therapy)
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