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Investigation into the effects in-vitro of the 5-hydroxytryptamine reuptake inhibitor, alaproclate, on carbachol-stimulated inositol phospholipid breakdown in the rat cerebral cortex.

Abstract
The effect of alaproclate in carbachol-stimulated inositol phospholipid (PI) breakdown in rat cerebral cortical miniprisms has been investigated. Carbachol-stimulated PI breakdown was greatly enhanced by increasing the assay potassium concentration from 5.88 to 18.2 mM. Alaproclate, on the other hand, did not influence carbachol-stimulated PI breakdown over the concentration range tested (0-100 microM) at either assay [K+]. The elution pattern of the inositol phosphates from the Dowex-1 columns was also unaffected by alaproclate both in the absence and presence of carbachol. Thus, the potentiation by alaproclate of tremor and salivation induced by the muscarinic agonist oxotremorine in-vivo reported previously is not seen when muscarinic function is measured in-vitro using carbachol-stimulated PI breakdown.
AuthorsC J Fowler, G Thorell, S O Ogren
JournalThe Journal of pharmacy and pharmacology (J Pharm Pharmacol) Vol. 39 Issue 12 Pg. 1015-8 (Dec 1987) ISSN: 0022-3573 [Print] England
PMID2894427 (Publication Type: Journal Article)
Chemical References
  • Antidepressive Agents
  • Inositol Phosphates
  • Sugar Phosphates
  • Inositol
  • Carbachol
  • alaproclate
  • Alanine
Topics
  • Alanine (analogs & derivatives, pharmacology)
  • Animals
  • Antidepressive Agents (pharmacology)
  • Carbachol (pharmacology)
  • Cerebral Cortex (drug effects, metabolism)
  • In Vitro Techniques
  • Inositol (metabolism)
  • Inositol Phosphates (metabolism)
  • Male
  • Rats
  • Rats, Inbred Strains
  • Sugar Phosphates (metabolism)

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