Abstract |
Liver parasite burdens of Leishmania donovani in the mouse have been determined after treatment with intravenous administration of sodium stibogluconate in the free or carrier form. The carrier form, in which the drug was covalently bound to polyacryl starch microparticles, was up to 100x more effective than the free form in this murine model of visceral leishmaniasis. Empty microparticles had no effect on liver parasite burdens and the enhanced in-vivo antileishmanial activity of the carrier form of the drug was apparently due to passive drug delivery to the infected liver.
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Authors | A J Baillie, G H Coombs, T F Dolan, C A Hunter, T Laakso, I Sjöholm, P Stjärnkvist |
Journal | The Journal of pharmacy and pharmacology
(J Pharm Pharmacol)
Vol. 39
Issue 10
Pg. 832-5
(Oct 1987)
ISSN: 0022-3573 [Print] England |
PMID | 2891821
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Excipients
- Gluconates
- Starch
- starch polyacrylate
- Antimony
- Antimony Sodium Gluconate
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Topics |
- Animals
- Antimony
(analysis)
- Antimony Sodium Gluconate
(administration & dosage, pharmacology)
- Biotransformation
- Cricetinae
- Excipients
- Female
- Gluconates
(administration & dosage)
- Leishmania donovani
- Leishmaniasis, Visceral
(drug therapy, parasitology)
- Liver
(parasitology)
- Mesocricetus
- Mice
- Mice, Inbred BALB C
- Microspheres
- Spectrophotometry, Atomic
- Starch
(analogs & derivatives)
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