[Metipranolol 0.1%: effect of a single dose on the nycthemeral pressure curve in an eye with chronic primary open-angle glaucoma].

Abstract

A double blind randomised study was made to compare the efficiency in decreasing intra ocular pressure of Metipranolol 0.1% or 0.3% versus placebo in three groups of 15 patients with chronic open angle glaucoma with or without visual field defects. The results demonstrate that Metipranolol 0.1% significantly lowers the intra ocular pressure in comparison with placebo. But this lowering is less that the one with 0.3% and is markedly reduced after 9 hours. The action of Metipranolol 0.3% is more durable and is still observed at 24 hours with a drop of nearly 20% in comparison with the initial intra ocular pressure. In the three groups, no significant variation of pulse and arterial pressure could be noticed during this 24 hours study.

• Authors: P Demailly, F Lecherpie
• Journal: Journal francais d'ophtalmologie (J Fr Ophtalmol) Vol. 10 Issue 6-7 Pg. 447-9 ( 1987) ISSN: 0181-5512 [Print] France
• Vernacular Title: Métipranolol 0.1%: l'effet d'une dose unique sur la courbe tensionnelle nycthémérale d'un oeil porteur d'un glaucome chronique primitif à angle ouvert.
• PMID: 2891739 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Ophthalmic Solutions
• Propanolamines
• Metipranolol

Topics

• Adult
• Aged
• Chronic Disease
• Circadian Rhythm
• Double-Blind Method
• Drug Evaluation
• Glaucoma, Open-Angle (drug therapy)
• Humans
• Intraocular Pressure (drug effects)
• Metipranolol (administration & dosage, pharmacology, therapeutic use)
• Middle Aged
• Ophthalmic Solutions
• Propanolamines (pharmacology, therapeutic use)
• Random Allocation
• Time Factors