Treatment of cryptorchidism with low doses of buserelin over a 6-months period.

Abstract

In a collaborative study, 48 prepubertal boys with undescended testes ranging in age from 15 months to 11 years were treated with low-dose intranasal buserelin following an every-other-day programme for a period of 6 months. Urinary LH, FSH, and testosterone were not altered during the treatment period. Boys over 7 years of age experienced a slight but significant rise in testosterone at the end of treatment. Testicular descent was achieved in only 17% of boys. In the remainder, bilateral testicular biopsies were obtained during orchiopexy. Grouped analysis showed a significant increase in the number of germ cells per tubule in both unilateral and bilateral cryptorchid boys, suggesting that buserelin treatment of the testis in a cryptorchid position is capable of improving fertility potential. If time-matched controls are compared to treated boys of the same age, again a significant difference is observed indicating that buserelin treatment does increase the germ cell count.

• Authors: F Hadziselimovic, D Huff, J Duckett, B Herzog, J Elder, H Snyder, M Buser
• Journal: European journal of pediatrics (Eur J Pediatr) Vol. 146 Suppl 2 Pg. S56-8 ( 1987) ISSN: 0340-6199 [Print] Germany
• PMID: 2891526 (Publication Type: Journal Article)

Chemical References

• Buserelin

Topics

• Administration, Intranasal
• Buserelin (administration & dosage, therapeutic use)
• Child
• Child, Preschool
• Cryptorchidism (drug therapy)
• Humans
• Infant
• Male
• Spermatozoa (drug effects)
• Time Factors