Topical levocabastine, a selective H1 antagonist, in seasonal allergic rhinoconjunctivitis.

Abstract

Sixty-six patients with seasonal allergic rhinitis due to birch pollens, participated in an efficacy evaluation of topically applied, nasal and ocular, levocabastine, a highly selective H1 antagonist. A single blind comparison was performed between nasal levocabastine and flunisolide, a topical glucocorticoid preparation. Ocular levocabastine was compared with topical naphazoline/antazoline eye drops. Nasal and ocular symptom scores were recorded during a 31-day period. Pollen counts of birch pollens were done simultaneously. A global assessment of treatment efficacy was also made. In the comparison between the ocular treatments a significantly higher number of patients cited levocabastine excellent--it also had the advantage of fewer daily administrations. For nasal symptom scores the topical glucocorticosteroid therapy was in favour by number of sneezes. As for side effects, 44% of the patients complained of local irritation from naphazoline/antazoline eye drops or flunisolide nasal spray, but none with the levocabastine preparations. Topical levocabastine may provide an interesting alternative in the treatment of allergic rhinoconjunctivitis.

• Authors: M Bende, U Pipkorn
• Journal: Allergy (Allergy) Vol. 42 Issue 7 Pg. 512-5 (Oct 1987) ISSN: 0105-4538 [Print] Denmark
• PMID: 2891316 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Histamine H1 Antagonists
• Ophthalmic Solutions
• Piperidines
• levocabastine

Topics

• Administration, Intranasal
• Adolescent
• Adult
• Conjunctivitis, Allergic (drug therapy)
• Female
• Histamine H1 Antagonists (therapeutic use)
• Humans
• Male
• Middle Aged
• Ophthalmic Solutions
• Piperidines (administration & dosage, therapeutic use)
• Random Allocation
• Rhinitis, Allergic, Seasonal (drug therapy)