Effects of dopamine receptor antagonists on gastrin and vomiting responses to apomorphine.

Abstract

Apomorphine (0.05 mg/kg intravenously) was given to conscious dogs, and gastrin levels were measured in peripheral venous blood with a radioimmunoassay. Apomorphine induced an increase of gastrin levels which peaked at 5 min. The peripheral dopamine D-2/DA2 receptor antagonist domperidone (0.2 mg/kg), but not halopemide (0.1-1 mg/kg) nor the D-1/DA1 receptor antagonist SCH 23,390 (0.1 mg/kg), blocked the gastrin response to apomorphine. Both domperidone and halopemide, but not SCH 23,390, blocked the apomorphine-induced vomiting. These results suggest that apomorphine increases gastrin levels by an action at D-2/DA2 receptors, which are situated outside the blood brain barrier and differ from the receptor inducing the vomiting.

• Authors: M Goiny, K Uvnäs-Moberg
• Journal: Naunyn-Schmiedeberg's archives of pharmacology (Naunyn Schmiedebergs Arch Pharmacol) Vol. 336 Issue 1 Pg. 16-9 (Jul 1987) ISSN: 0028-1298 [Print] Germany
• PMID: 2888024 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antipsychotic Agents
• Benzazepines
• Gastrins
• Receptors, Dopamine
• Tranquilizing Agents
• Domperidone
• halopemide
• Apomorphine

Topics

• Animals
• Antipsychotic Agents (pharmacology)
• Apomorphine (pharmacology)
• Benzazepines (pharmacology)
• Dogs
• Domperidone (analogs & derivatives, pharmacology)
• Female
• Gastrins (metabolism)
• Male
• Receptors, Dopamine (drug effects)
• Tranquilizing Agents
• Vomiting (chemically induced)