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The effects of mesterolone on sperm count in idiopathic oligospermia.

Abstract
Forty subfertile men with idiopathic oligospermia were randomly treated with mesterolone or with placebo for more than 4 months. Seminal analysis was performed thrice before treatment, and twice after 16 weeks of treatment. There was a significant increase of semen volume (P less than .05), mean sperm concentration (P less than .01), and mean total sperm count per ejaculate (P less than .01) with mesterolone therapy. Sperm motility and morphological characteristics were not modified by mesterolone therapy. Mesterolone was found to be effective in improving the sperm concentration in mild and moderate rather than in severe idiopathic oligospermia.
AuthorsR K Bhathena, M J Jassawalla, D N Patel
JournalInternational journal of fertility (Int J Fertil) 1987 Jul-Aug Vol. 32 Issue 4 Pg. 306-8 ISSN: 0020-725X [Print] United States
PMID2887529 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Dihydrotestosterone
  • Mesterolone
Topics
  • Adult
  • Dihydrotestosterone (analogs & derivatives)
  • Humans
  • Male
  • Mesterolone (therapeutic use)
  • Oligospermia (drug therapy)
  • Random Allocation
  • Semen (analysis)
  • Sperm Count (drug effects)
  • Time Factors

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