Abstract |
A linkage study was carried out in nine families with 24 males affected by X-linked recessive retinoschisis (RS), using three polymorphic DNA probes from the distal segment of Xp. Close linkage of the disease locus with markers DXS41 (probe p99-6) and DXS16 (pXUT23) was found, confirming the location of the RS gene on the distal short arm of the X chromosome. Lod scores for linkage with DXS85 (probe 782) were negative.
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Authors | T Alitalo, J Kärnä, H Forsius, A de la Chapelle |
Journal | Clinical genetics
(Clin Genet)
Vol. 32
Issue 3
Pg. 192-5
(Sep 1987)
ISSN: 0009-9163 [Print] Denmark |
PMID | 2887320
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Genes, Recessive
- Genetic Linkage
- Genetic Markers
- Humans
- Male
- Polymorphism, Restriction Fragment Length
- Retinal Perforations
(genetics)
- X Chromosome
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