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Zuclopenthixol acetate in Viscoleo--a new drug formulation. An open Nordic multicentre study of zuclopenthixol acetate in Viscoleo in patients with acute psychoses including mania and exacerbation of chronic psychoses.

Abstract
Eighty-three acutely disturbed, psychotic patients were included in an open multicentre study. The aim of the study was to evaluate the clinical effect of zuclopenthixol acetate in Viscoleo (CPT-A). Each patient received from one to four intramuscular injections of CPT-A during the 6-day study period. The duration of action after one injection was between 2 and 3 days and doses from 50 mg to 150 mg were sufficient for most patients. Treatment with CPT-A caused a pronounced and rapid reduction of the psychotic symptoms. At the end of the 6-day test period the mean total score on BPRS in acute non-manic and exacerbated chronic patients was reduced by more than 50 per cent. In acute manic patients the mean total score on BRMS was reduced by 57 per cent already 1 day after injection. Rapidly after the injection of CPT-A a useful short-acting sedation can be expected, but the risk for oversedation even after a second injection is low. The frequency of unwanted effects, including extrapyramidal reactions, was low and the severity of symptoms was most often mild. With a rapid onset of action, a duration of effect of 2 to 3 days, and few and mild side effects, CPT-A offers advantages over the neuroleptic preparations conventionally used in the initial treatment of acutely disturbed, psychotic patients.
AuthorsA Amdisen, M S Nielsen, S J Dencker, C Fensbo, U G Ahlfors, A Gravem, P C Baastrup, L Bjerkenstedt, B Gunby, F A Wiesel
JournalActa psychiatrica Scandinavica (Acta Psychiatr Scand) Vol. 75 Issue 1 Pg. 99-107 (Jan 1987) ISSN: 0001-690X [Print] United States
PMID2883816 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Antipsychotic Agents
  • Thioxanthenes
  • clopenthixol decanoate
  • Clopenthixol
Topics
  • Acute Disease
  • Adolescent
  • Adult
  • Antipsychotic Agents (adverse effects, therapeutic use)
  • Bipolar Disorder (drug therapy)
  • Clinical Trials as Topic
  • Clopenthixol (adverse effects, analogs & derivatives, therapeutic use)
  • Female
  • Humans
  • Injections, Intramuscular
  • Male
  • Middle Aged
  • Psychiatric Status Rating Scales
  • Psychotic Disorders (drug therapy)
  • Thioxanthenes (therapeutic use)

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