Abstract |
Eighty-three acutely disturbed, psychotic patients were included in an open multicentre study. The aim of the study was to evaluate the clinical effect of zuclopenthixol acetate in Viscoleo ( CPT-A). Each patient received from one to four intramuscular injections of CPT-A during the 6-day study period. The duration of action after one injection was between 2 and 3 days and doses from 50 mg to 150 mg were sufficient for most patients. Treatment with CPT-A caused a pronounced and rapid reduction of the psychotic symptoms. At the end of the 6-day test period the mean total score on BPRS in acute non-manic and exacerbated chronic patients was reduced by more than 50 per cent. In acute manic patients the mean total score on BRMS was reduced by 57 per cent already 1 day after injection. Rapidly after the injection of CPT-A a useful short-acting sedation can be expected, but the risk for oversedation even after a second injection is low. The frequency of unwanted effects, including extrapyramidal reactions, was low and the severity of symptoms was most often mild. With a rapid onset of action, a duration of effect of 2 to 3 days, and few and mild side effects, CPT-A offers advantages over the neuroleptic preparations conventionally used in the initial treatment of acutely disturbed, psychotic patients.
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Authors | A Amdisen, M S Nielsen, S J Dencker, C Fensbo, U G Ahlfors, A Gravem, P C Baastrup, L Bjerkenstedt, B Gunby, F A Wiesel |
Journal | Acta psychiatrica Scandinavica
(Acta Psychiatr Scand)
Vol. 75
Issue 1
Pg. 99-107
(Jan 1987)
ISSN: 0001-690X [Print] United States |
PMID | 2883816
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Antipsychotic Agents
- Thioxanthenes
- clopenthixol decanoate
- Clopenthixol
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Topics |
- Acute Disease
- Adolescent
- Adult
- Antipsychotic Agents
(adverse effects, therapeutic use)
- Bipolar Disorder
(drug therapy)
- Clinical Trials as Topic
- Clopenthixol
(adverse effects, analogs & derivatives, therapeutic use)
- Female
- Humans
- Injections, Intramuscular
- Male
- Middle Aged
- Psychiatric Status Rating Scales
- Psychotic Disorders
(drug therapy)
- Thioxanthenes
(therapeutic use)
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