Coffee consumption after myocardial infarction and risk of cardiovascular mortality: a prospective analysis in the Alpha Omega Cohort.

Abstract

Background: Consumption of coffee, one of the most popular beverages around the world, has been associated with a lower risk of cardiovascular and all-cause mortality in population-based studies. However, little is known about these associations in patient populations.Objective: This prospective study aimed to examine the consumption of caffeinated and decaffeinated coffee in relation to cardiovascular disease (CVD) mortality, ischemic heart disease (IHD) mortality, and all-cause mortality in patients with a prior myocardial infarction (MI).Design: We included 4365 Dutch patients from the Alpha Omega Cohort who were aged 60-80 y (21% female) and had experienced an MI <10 y before study enrollment. At baseline (2002-2006), dietary data including coffee consumption over the past month was collected with a 203-item validated food-frequency questionnaire. Causes of death were monitored until 1 January 2013. HRs for mortality in categories of coffee consumption were obtained from multivariable Cox proportional hazard models, adjusting for lifestyle and dietary factors.Results: Most patients (96%) drank coffee, and the median total coffee intake was 375 mL/d (∼3 cups/d). During a median follow-up of 7.1 y, a total of 945 deaths occurred, including 396 CVD-related and 266 IHD-related deaths. Coffee consumption was inversely associated with CVD mortality, with HRs of 0.69 (95% CI: 0.54, 0.89) for >2-4 cups/d and 0.72 (0.55, 0.95) for >4 cups/d, compared with 0-2 cups/d. Corresponding HRs were 0.77 (95% CI: 0.57, 1.05) and 0.68 (95% CI: 0.48, 0.95) for IHD mortality and 0.84 (95% CI: 0.71, 1.00) and 0.82 (95% CI: 0.68, 0.98) for all-cause mortality, respectively. Similar associations were found for decaffeinated coffee and for coffee with additives.Conclusion: Drinking coffee, either caffeinated or decaffeinated, may lower the risk of CVD and IHD mortality in patients with a prior MI. This study was registered at clinicaltrials.gov as NCT03192410.

• Authors: Laura H van Dongen, Famke Jm Mölenberg, Sabita S Soedamah-Muthu, Daan Kromhout, Johanna M Geleijnse
• Journal: The American journal of clinical nutrition (Am J Clin Nutr) Vol. 106 Issue 4 Pg. 1113-1120 (Oct 2017) ISSN: 1938-3207 [Electronic] United States
• PMID: 28835365 (Publication Type: Journal Article)
• Copyright: © 2017 American Society for Nutrition.

Chemical References

• Coffee
• Caffeine

Topics

• Aged
• Caffeine (pharmacology)
• Cardiovascular Diseases (mortality)
• Cause of Death
• Coffea
• Coffee
• Diet
• Female
• Follow-Up Studies
• Humans
• Life Style
• Male
• Middle Aged
• Myocardial Infarction (complications)
• Myocardial Ischemia (mortality)
• Netherlands
• Nutrition Surveys
• Proportional Hazards Models
• Prospective Studies
• Risk
• Risk Factors
• Surveys and Questionnaires