Therapeutic effects of the bis-pyridinium salts HGG-12, HGG-42, and atropine, benactyzine in organophosphate poisoning of dogs.

Abstract

Therapeutic properties of various combinations of the bispyridinium salts HGG-12 and HGG-42 against soman and sarin poisoning were investigated in male beagles. Best therapeutic efficiency was shown by HGG-42 in a dosage of 30 muMol/kg. Also good effects were produced by the combination of both oximes in a low dosage of 3 muMol/kg for each one. In soman poisoning no significant reactivation of cholinesterase in serum or erythrocytes was observed.

• Authors: W Hauser, N Weger
• Journal: Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement (Arch Toxicol Suppl) Issue 2 Pg. 393-6 ( 1979) ISSN: 0171-9750 [Print] Germany
• PMID: 288351 (Publication Type: Journal Article)

Chemical References

• Antidotes
• Cholinesterase Inhibitors
• Organothiophosphorus Compounds
• Pyridinium Compounds
• Benactyzine
• Atropine
• Soman
• Sarin
• Aspartate Aminotransferases
• Creatine Kinase
• Cholinesterases

Topics

• Animals
• Antidotes
• Aspartate Aminotransferases (blood)
• Atropine (therapeutic use)
• Benactyzine (therapeutic use)
• Cholinesterase Inhibitors (poisoning)
• Cholinesterases (blood)
• Creatine Kinase (blood)
• Dogs
• Lethal Dose 50
• Male
• Organothiophosphorus Compounds (poisoning)
• Pyridinium Compounds (therapeutic use)
• Sarin (poisoning)
• Soman (poisoning)