[Comparison of granisetron and lidocaine on reducing injection pain of etomidate: a controlled randomized study].

Abstract

BACKGROUND AND OBJECTIVES:

Reducing pain on injection of anesthetic drugs is of importance to every anesthesiologist. In this study we pursued to define if pretreatment by granisetron reduces the pain on injection of etomidate similar to lidocaine.

METHODS:

Thirty patients aged between 18 and 50 years of American Society of Anesthesiologists physical status class I or II, whom were candidates for elective laparoscopic cholecystectomy surgery were enrolled in this study. Two 20 gauge cannulas were inserted into the veins on the dorsum of both hands and 100mL of normal saline was administered during a 10min period from each cannula. Using an elastic band as a tourniquet, venous drainage of both hands was occluded. 2mL of granisetron was administered into one hand and 2mL of lidocaine 2% at the same time into the other hand. One minute later the elastic band was opened and 2mL of etomidate was administered to each hand with equal rates. The patients were asked to give a score from 0 to 10 (0=no pain, 10=severe pain) to each the pain sensed in each hand.

RESULTS:

Two patients were deeply sedated after injection of etomidate and unable to answer any questions. The mean numerical rating score for injection pain of intravenously administered etomidate after intravenous granisetron was 2.3±1.7, which was lower when compared with pain sensed due to intravenously administered etomidate after administration of lidocaine 2% (4.6±1.8), p<0.05.

CONCLUSION:

The result of this study demonstrated that, granisetron reduces pain on injection of etomidate more efficiently than lidocaine.

• Authors: Alireza Saliminia, Omid Azimaraghi, Amir Javadi, Maryam Abdoulahpoor, Ali Movafegh
• Journal: Revista brasileira de anestesiologia (Rev Bras Anestesiol) 2017 Nov - Dec Vol. 67 Issue 6 Pg. 615-618 ISSN: 1806-907X [Electronic] Brazil
• Vernacular Title: Comparação de granisetrona e lidocaína na redução da dor causada pela injeção de etomidato: estudo randômico e controlado.
• PMID: 28826968 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2017. Publicado por Elsevier Editora Ltda.

Chemical References

• Anesthetics, Intravenous
• Lidocaine
• Granisetron
• Etomidate

Topics

• Adult
• Anesthetics, Intravenous (adverse effects)
• Double-Blind Method
• Etomidate (adverse effects)
• Female
• Granisetron (therapeutic use)
• Humans
• Injections, Intravenous
• Lidocaine (therapeutic use)
• Male
• Middle Aged
• Pain (chemically induced, drug therapy)
• Pain Management (methods)