Antral gastrin and somatostatin cell populations in rats after chronic administration of histamine.

Abstract

Variations in the size of the antral G and D cell populations under the effect of chronic stimulation of acid secretion with histamine were investigated in male Wistar rats. Osmotic minipumps delivering either 0.9% saline or histamine dihydrochloride (4.5 mg/kg/h) were implanted subcutaneously in gastric-fistula rats. Gastric secretion was collected prior to the implantation of the pump, after 7 days and after 14 days. Total antral G and D cell numbers and the G/D ratio were estimated at the end of the experiment. Administration of histamine during 14 days did not induce significant changes in the number of either G or D cells in the antrum despite a 3-fold increase in acid secretion.

• Authors: P Haentjens, E Beckers, G Willems
• Journal: Digestion (Digestion) Vol. 36 Issue 1 Pg. 1-6 ( 1987) ISSN: 0012-2823 [Print] Switzerland
• PMID: 2881823 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Gastrins
• Somatostatin
• Histamine

Topics

• Animals
• Cell Count
• Gastric Acid (metabolism)
• Gastric Mucosa (cytology, drug effects)
• Gastrins (metabolism)
• Histamine (administration & dosage, pharmacology)
• Immunoenzyme Techniques
• Male
• Pyloric Antrum (cytology, drug effects, metabolism)
• Rats
• Rats, Inbred Strains
• Somatostatin (metabolism)