Antral gastrin and somatostatin cell populations in rats after chronic administration of histamine.

Variations in the size of the antral G and D cell populations under the effect of chronic stimulation of acid secretion with histamine were investigated in male Wistar rats. Osmotic minipumps delivering either 0.9% saline or histamine dihydrochloride (4.5 mg/kg/h) were implanted subcutaneously in gastric-fistula rats. Gastric secretion was collected prior to the implantation of the pump, after 7 days and after 14 days. Total antral G and D cell numbers and the G/D ratio were estimated at the end of the experiment. Administration of histamine during 14 days did not induce significant changes in the number of either G or D cells in the antrum despite a 3-fold increase in acid secretion.
AuthorsP Haentjens, E Beckers, G Willems
JournalDigestion (Digestion) Vol. 36 Issue 1 Pg. 1-6 ( 1987) ISSN: 0012-2823 [Print] SWITZERLAND
PMID2881823 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Gastrins
  • Somatostatin
  • Histamine
  • Animals
  • Cell Count
  • Gastric Acid (secretion)
  • Gastric Mucosa (cytology, drug effects)
  • Gastrins (secretion)
  • Histamine (administration & dosage, pharmacology)
  • Immunoenzyme Techniques
  • Male
  • Pyloric Antrum (cytology, drug effects, secretion)
  • Rats
  • Rats, Inbred Strains
  • Somatostatin (secretion)

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