The effect of levobunolol on aqueous humor dynamics.

Abstract

We evaluated the acute effects of installation of 0.5% levobunolol on aqueous humor dynamics in a double-masked study in 18 patients with ocular hypertension. Aqueous flow was measured by fluorophotometry and total outflow facility by tonography. Aqueous flow decreased approximately 29% in the eyes treated with levobunolol. Total outflow facility and episcleral venous pressure measurements were similar in levobunolol-treated eyes and contralateral eyes treated with vehicle. A 36% decrease in intraocular pressure was observed in the levobunolol-treated eyes and a slight intraocular pressure reduction was seen in the vehicle-treated eyes. The results of this study indicate that, similar to timolol, levobunolol lowers intraocular pressure primarily by decreasing aqueous humour production.

• Authors: M E Yablonski, G D Novack, P J Burke, D J Cook, G Harmon
• Journal: Experimental eye research (Exp Eye Res) Vol. 44 Issue 1 Pg. 49-54 (Jan 1987) ISSN: 0014-4835 [Print] England
• PMID: 2881799 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Adrenergic beta-Antagonists
• Levobunolol

Topics

• Adrenergic beta-Antagonists (pharmacology)
• Aqueous Humor (drug effects, physiology)
• Female
• Humans
• Intraocular Pressure (drug effects)
• Levobunolol (pharmacology)
• Male
• Middle Aged
• Ocular Hypertension (physiopathology)
• Stereoisomerism
• Venous Pressure (drug effects)