Establishment of valnemulin susceptibility breakpoint against Clostridium perfringens in rabbits.

Abstract

Susceptibility breakpoints provide fundamental information for rational administration of antibiotics. The present investigation reports the first valnemulin susceptibility breakpoint (MIC<0.25 μg/mL) against Clostridium perfringens infections in rabbits based on the wild-type cutoff (COWT) and the pharmacokinetics/pharmacodynamic (PK/PD) cutoff (COPD). The established susceptibility breakpoint of valnemulin might be useful in resistance surveillance of pleuromutilins and development of clinical breakpoints.

• Authors: Meng-Ting Tao, Yu-Feng Zhou, Jian Sun, Ya-Hong Liu, Xiao-Ping Liao
• Journal: Anaerobe (Anaerobe) Vol. 48 Pg. 118-120 (Dec 2017) ISSN: 1095-8274 [Electronic] England
• PMID: 28801120 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 Elsevier Ltd. All rights reserved.

Chemical References

• Anti-Bacterial Agents
• Diterpenes
• valnemulin

Topics

• Animal Diseases (drug therapy, microbiology)
• Animals
• Anti-Bacterial Agents (administration & dosage, pharmacokinetics, pharmacology)
• Clostridium Infections (veterinary)
• Clostridium perfringens (drug effects)
• Diterpenes (administration & dosage, pharmacokinetics, pharmacology)
• Microbial Sensitivity Tests
• Rabbits